A NEW SYNTHETIC APPROACH TO PENTACYCLIC RING, 6,7,14,15-TETRAHYDRO[1,5]DIAZOCINO[1,2-a:6,5-a ']-8-DIHYDRODIINDOLE

作者：Sripha Kittisak^*; Zlotos Darius Paul; Holzgrabe Ulrike; Ruchirawat Somsak

来源：Heterocycles, 2011, 83(11): 2627-2633.

DOI：10.3987/COM-11-12340

• New Pentacyclic Ring System
• Intramolecular N-Alkylation
• N-Acylation
• Tosylation
• Cyclization

The construction of a new pentacyclic ring system, 6,7,14,15-tetrahydro[1,5]diazocino[1,2-a:6,5-a']-8-dihydrodiindole (7) from simple precursors through our new synthetic route was presented to be a facile and concise method for an intramolecular N-alkylation of tosylate 12 which was obtained from N-acylation of indoline 4 with indole acid 9, followed by reduction and tosylation. This new synthetic approach can overcome the disadvantage of uncontrollable intermolecular double N-alkylation of the precursor 3 to produce the unexpected ring system 2.

• 出版日期2011-11-1