Drugging ACAT1 for Cancer Therapy

作者：Garcia Bermudez Javier; Birsoy Kivanc^*

来源：Molecular Cell, 2016, 64(5): 856-857.

DOI：10.1016/j.molcel.2016.11.023

In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.

• 出版日期2016-12-1