Sex and Circadian Periodicity of Cardiovascular Diseases Are Women Sufficiently Represented in Chronobiological Studies?

作者：Manfredini Roberto^*; Salmi Raffaella; Cappadona Rosaria; Signani Fulvia; Basili Stefania; Katsiki Niki

来源：Heart Failure Clinics, 2017, 13(4): 719-+.

DOI：10.1016/j.hfc.2017.05.008

• Biological rhythms
• Circadian rhythm
• Sex
• Clinical studies
• Myocardial infarction
• Aortic aneurysm
• rupture and dissection
• Cerebrovascular disease
• Stroke
• Sudden cardiac death

Women are often excluded/underrepresented in clinical trials; sometimes, the number of men/women participants or separate analysis by sex are not reported. A robust body of evidence demonstrated that several life-threatening acute cardiovascular diseases, for example, acute myocardial infarction, sudden cardiac death, cardiac arrest, rupture or dissection of aortic aneurysms, and stroke, exhibit a circadian periodicity with a morning peak. An analysis of 20 years of chronobiologic studies (44% of them, accounting for 85% of total cases, with separate analysis by sex) confirmed that morning hours are a critical time of onset of acute cardiovascular diseases in men and women.

• 出版日期2017-10