Doppler changes in the vertebral, middle cerebral, and umbilical arteries in fetuses delivered after 34 weeks: relationship to severity of growth restriction

作者：Morales Rosello Jose; Hervas Marin David; Fillol Crespo Manuel; Perales Marin Alfredo

来源：Prenatal Diagnosis, 2012, 32(10): 960-967.

DOI：10.1002/pd.3941

Objective To determine the association between Doppler changes in the fetal vertebral (VA), middle cerebral (MCA), and umbilical arteries (UA) and severity of growth restriction (FGR) in fetuses delivered after 34?weeks. Method Five hundred seventy-one Doppler examinations of the VA, MCA, and UA were performed between 26 and 41?weeks of gestation. Values were converted into multiples of the median and divided into birth weight (BW) categories: BW>P10th, BW<P10th, BW<P5th, and BW<P3rd. Differences were evaluated and multivariate logistic regression models plus receiver-operating characteristic curves were calculated to determine the accuracy of Doppler measurements for the prediction of FGR percentiles. Results The UA pulsatility index (PI) was significant predicting BW<P10th and BW<P3rd, the VA PI was significant predicting BW<P5th and BW<P3rd. Finally, the MCA PI was not predictive of any degree of severity of FGR. In addition, only VA and UA differences were statistically significant. Conclusion In fetuses delivered after 34?weeks, mild degrees of growth restriction are better associated with high UA PI whereas severe degrees are associated with low VA PI but not with low MCA PI.

• 出版日期2012-10