Dietary D-Allose Ameliorates Hepatic Inflammation in Mice with Non-alcoholic Steatohepatitis

作者：Yamamoto Ryoko; Iida Ayaka; Tankawa Ken; Shiratsuchi Hideki; Tokuda Masaaki; Matsui Toshiro; Nakamura Tsuyoshi

来源：Food Science and Technology Research, 2017, 23(2): 319-327.

DOI：10.3136/fstr.23.319

• nonalcoholic fatty liver disease
• nonalcoholic steatohepatitis
• rare sugar
• D-allose

Nonalcoholic steatohepatitis (NASH) is characterized by excess lipid accumulation and inflammation in hepatocytes. In this study, to provide insight into the preventive effects of D-allose, a rare sugar, on the onset of NASH, we designed animal experiments using male STAM mice treated with streptozotocin and fed a high-fat diet (HFD). Experiments were initiated when the mice reached 5 weeks of age and lasted 3 weeks. After the 3-week protocol, mice fed the HFD containing D-allose exhibited significantly decreased serum alanine aminotransferase levels, hepatic lipid accumulation and inflammation, and improved nonalcoholic fatty liver disease activity score compared to mice fed HFD without D-allose (p < 0.05). Further, hepatic mRNA expression of sterol regulatory element binding protein-1 (Srebp-1) and monocyte chemotactic protein-1 (Mcp-1) was lower in mice fed D-allose. These results suggested that D-allose prevented NASH by blocking hepatic lipid accumulation and progressive inflammation.

• 出版日期2017-3