Atorvastatin prevents type 2 diabetes mellitus-An experimental study

作者：Madhu Venkata^*; Aslam Mohammad; Galav Vikas; Bhattacharya Swapan Kumar; Jafri Aiman Abbas

来源：European Journal of Pharmacology, 2014, 728: 135-140.

DOI：10.1016/j.ejphar.2014.01.069

• Atorvastatin
• Hypertriglyceridemia
• Glucose area under the curve
• Insulin resistance
• Impaired glucose tolerance
• Type 2 diabetes

Recent reports of increased diabetes risk have raised concerns regarding the use of stains. The present study was therefore planned to clarify whether atorvastatin can prevent diabetes development in a rat model of type 2 diabetes mellitus. Eight week old male Wistar rats were randomized into three groups (n = 12 each group). Group A was given standard chow diet, while group B and group C were offered high sucrose diet. In addition to high sucrose diet, group C was given atorvastatin (20 mg/kg/day) from beginning of study till 26th week. After 26 weeks, a low dose of streptozotocin (15 mg/kg, i.p.) was given to all 3 groups and further followed for 4 weeks. Oral glucose tolerance tests were done at week 4,26 and week 30. Development of impaired glucose tolerance at week 26 (16.66% vs 100%, P = < 0.001) and diabetes at week 30 (16.66% vs 81.81%, P=0.002) was significantly lower in rats pretreated with atorvastatin along with high sucrose diet viz group C compared to group B rats who received high sucrose diet only respectively. Also, metabolic indices like body weight, hypertriglyceridemia, glucose area under the curve (Gl-AUC) were significantly lower in group C compared to group B (P= < 0.05) while insulin resistance (HOMA-IR) was also lower in group C (P=0.05). This study clearly demonstrates for the first time in a rat model of type 2 diabetes mellitus that atorvastatin prevents development of type 2 diabetes.

• 出版日期2014-4-5