A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-kappa B mediated apoptosis-to-pyroptosis switch

作者：Chen, Liping; Weng, Bixia; Li, Huimin; Wang, Haonan; Li, Qian; Wei, Xiaoyan; Deng, Hui; Wang, Sicen; Jiang, Chengxi; Lin, Renyu^*; Wu, Jianzhang^*

来源：Apoptosis, 2019, 24(1-2): 74-82.

DOI：10.1007/s10495-018-1499-y

• Anti-lung cancer
• Toxicity
• Apoptosis
• Pyroptosis
• NF-kappa B

Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-B signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.

• 出版日期2019-2
• 单位西安交通大学; 温州医科大学; 浙江省肿瘤医院