Development of DNA-Based Hybrid Catalysts through Direct Ligand Incorporation: Toward Understanding of DNA-Based Asymmetric Catalysis

作者：Park Soyoung^*; Zheng Linjie; Kumakiri Shunsuke; Sakashita Sohei; Otomo Haruka; Ikehata Keiichi; Sugiyama Hiroshi

来源：ACS Catalysis, 2014, 4(11): 4070-4073.

DOI：10.1021/cs501086f

• DNA
• hybrid catalyst
• asymmetric catalysis
• Friedel-Crafts reaction
• direct ligand incorporation

We have developed a DNA-based hybrid catalyst containing an intrastrand bipyridine ligand through direct ligand incorporation and successfully performed asymmetric intramolecular FriedelCrafts alkylations. This is the first report on the DNA hybrid catalyst system where an intrastrand ligand is covalently introduced into the phosphate backbone. We have generated a series of active site to investigate the structural details of DNA hybrid catalysts and demonstrated that catalytic properties of DNA hybrid catalysts are governed by the disposition of the metal-binding site in the DNA duplex, the size of catalytic cavity, and the composition of nucleobases in the catalytic pocket.

• 出版日期2014-11