Beyond replication: Division and segregation of mitochondrial DNA in kinetoplastids

作者：Povelones Megan L^*

来源：Molecular and Biochemical Parasitology, 2014, 196(1): 53-60.

DOI：10.1016/j.molbiopara.2014.03.008

• Kinetoplast
• kDNA
• Trypanosoma brucei
• Kinetoplastids
• Mitochondria
• Mitochondrial DNA

The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.

• 出版日期2014-8