A soluble-polymer system for the asymmetric transfer hydrogenation of ketones

作者：Bastin S; Eaves RJ; Edwards CW; Ichihara O; Whittaker M; Wills M^*

来源：Journal of Organic Chemistry, 2004, 69(16): 5405-5412.

DOI：10.1021/jo049479u

The appropriate combination of methaerylate polymers permits the synthesis of a soluble polymer for use in ruthenium(II)-catalyzed asymmetric transfer hydrogenation reactions. Using a 7:3 copolymer of a poly(ethylene glycol) ester and a hydroxyethyl ester, a derived ruthenium(II)/ norephedrine complex catalyses reduction of acetophenone in up to 95% yield and 81% ee.

• 出版日期2004-8-6