A NEW HUMAN SLOW SKELETAL TROPONIN-T (TNTS) MRNA ISOFORM DERIVED FROM ALTERNATIVE SPLICING OF A SINGLE-GENE

作者：SAMSON F^*; MESNARD L; MIHOVILOVIC M; POTTER TG; MERCADIER JJ; ROSES AD; GILBERT JR

来源：Biochemical and Biophysical Research Communications, 1994, 199(2): 841-847.

DOI：10.1006/bbrc.1994.1305

A human muscle cDNA library was screened for slow skeletal troponin T (TnTs). Sequence analysis revealed that one of the selected clones had a cDNA coding sequence different from the two previously described. RNase protection assays confirmed the expression of this new isoform in adult skeletal muscle. In addition, results of the RNase protection assays strongly suggested the expression of a fourth isoform. These isoforms for human slow TnT most likely result from combinatorial alternative splicing of a single gene.

• 出版日期1994-3-15