Diastereoselective 1,3-Dipolar Cycloadditions of N,N′-Cyclic Azomethine Imines with Iminooxindoles for Access to Oxindole Spiro-N,N-bicyclic Heterocycles

作者：Zhao, Hong-Wu^*; Li, Bo; Pang, Hai-Liang; Tian, Ting; Chen, Xiao-Qin; Song, Xiu-Qing; Meng, Wei; Yang, Zhao; Zhao, Yu-Di; Liu, Yue-Yang

来源：Organic Letters, 2016, 18(4): 848-851.

DOI：10.1021/acs.orglett.6b00139

• CATALYZED 3+2 CYCLOADDITION
• HIGHLY ENANTIOSELECTIVE ADDITION
• MANNICH REACTION
• CONSTRUCTION

In the presence of CuI, 1,3-dipolar cycloadditions of N,N'-cyclic azomethine imines with iminooxindoles proceeded readily and furnished novel oxindole spiro-N,N-bicyclic heterocycles in moderate to excellent chemical yields with excellent diastereoselectivities.

• 出版日期2016-2-19
• 单位北京工业大学