Changes in Tumor Volume of Sacral Chordoma After Carbon Ion Radiotherapy

作者：Serizawa Itsuko; Phd Reiko ImaiMd; Kamada Tadashi^*; Tsuji Hiroshi; Kishimoto Riwa; Kandatsu Susumu; Tsujii Hirohiko; Tatezaki Shin ichiro

来源：Journal of Computer Assisted Tomography, 2009, 33(5): 795-798.

DOI：10.1097/rct.0b013e31818f0d49

• chordoma
• charged particle therapy
• radiotherapy
• magnetic resonance (MR) imaging

Objective: we evaluated changes in tumor volume in cases of sacral chordoma after carbon ion radiotherapy.
Methods: Thirty-four patients with sacral chordoma underwent carbon ion radiotherapy between June 1996 and June 2003. We assessed 23 patients without previous surgery using T2-weighted magnetic resonance imaging. The tumor volume was calculated semiautomatically.
Results: Two cases showed local recurrence. The median interval of this examination was 46 months. At the end of the treatment, the tumor showed ail enlargement larger than 10% of its volume in 13 of the 23 cases, no change in 4 cases, and regression in 6 cases. At the last examination, 20 cases showed a reduction in tumor volume, and the median ratio, determined as the tumor volume at the last examination divided by that before the treatment, was 0.36.
Conclusions: An increase in tumor volume at the end of the treatment does not indicate the ineffectiveness of carbon ion radiotherapy.

• 出版日期2009-10