Analysis of dose-volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer

作者：Asakura Hirofumi^*; Hashimoto Takayuki; Zenda Sadamoto; Harada Hideyuki; Hirakawa Koichi; Mizumoto Masashi; Furutani Kazuhisa; Hironaka Shuichi; Fuji Hiroshi; Murayama Shigeyuki; Boku Narikazu; Nishimura Tetsuo

来源：Radiotherapy and Oncology, 2010, 95(2): 240-244.

DOI：10.1016/j.radonc.2010.02.006

• Esophageal cancer
• Chemoradiotherapy
• Radiation pneumonitis
• Dose-volume histogram

Purpose: To evaluate dose-volume histogram (DVH) parameters as predictors of radiation pneumonitis (RP) in esophageal cancer patients treated with definitive concurrent chemoradiotherapy.
Patients and methods: Thirty-seven esophageal cancer patients treated with radiotherapy with concomitant chemotherapy consisting of 5-fluorouracil and cisplatin were reviewed. Radiotherapy was delivered at 2 Gy per fraction to a total of 60 Gy. For most of the patients, two weeks of interruption was scheduled after 30 Gy. The percentage of lung volume receiving more than 5-50 Gy in increments of 5 Gy (V5-V50, respectively), and the mean lung dose (MLD) were analyzed.
Results: Ten (27%) patients developed RP of grade 2; 2 (5%), grade 3: 0 (0%), grade 4; and 1 (3%), grade 5. By univariate analysis, all DVH parameters (i.e., V5-V50 and MLD) were significantly associated with grade >= 2 RP (p < 0.01). The incidences of grade >= 2 RP were 13%, 33%, and 78% in patients with V20s of <= 24%, 25-36%, and >= 37% respectively. The optimal V20 threshold to predict symptomatic RP was 30.5% according to the receiver operating characteristics curve analysis.
Conclusion: DVH parameters were predictors of symptomatic RP and should be considered in the evaluation of treatment planning for esophageal cancer.

• 出版日期2010-5