Comparison of survival and pathological features of signet-ring cell carcinoma of the colon between young and elderly patients

作者：Huang, Ben; Mo, Shaobo; Ni, Mengdong; Chen, Chen; Cai, Guoxiang; Cai, Sanjun^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(11): 11736-11743.

• Colon cancer
• signet-ring cell carcinoma
• age
• survival

Background: Signet-ring cell carcinoma (SRCC), a rare histological type of colon cancer, is associated with aggressive biological behavior and poor prognosis. Here, we aim to compare the clinicopathological features and the survival outcomes between young and elderly patients with SRCC of the colon without distant metastasis. Methods: We analyzed patients with non-metastatic SRCC of the colon in the Surveillance, Epidemiology and End Results (SEER) database. Patients were divided into three groups based on age: group 1 (<= 30 years), group 2 (30-60 years) and group 3 (> 60 years). A multivariate Cox proportional hazards model was performed to analyze risk factors for cancer-specific survival (CSS). Results: In all, 803 patients were included in the analysis. A higher proportion of stage III disease and N2 disease was found in patients in group 1 compared with patients in group 2 and group 3. The Kaplan-Meier analysis showed increasing CSS with increasing age (P<0.001): the 5-year CSS was 21.9% for patients in group 1, 52.3% for patients in group 2 and 56.6% for patients in group 3. A multivariate analysis indicated that age was an independent prognostic factor for CSS (P= 0.045). Compared with patients in group 1, patients in group 2 were more likely to exhibit a greater CSS (HR 0.610, 95% CI 0.413-0.900, P= 0.013), as were patients in group 3 (HR 0.673, 95% CI 0.454-0.997, P= 0.048). Conclusions: Young patients are associated with poor CSS, as well as with advanced tumor stage and extensive lymph node involvement in SRCC of the colon without distant metastasis.

• 出版日期2016
• 单位复旦大学