A well-defined unimolecular channel facilitates chloride transport

作者：Chen, Sujun; Zhao, Yongliang; Bao, Chunyan^*; Zhou, Yaowu; Wang, Chenxi; Lin, Qiuning; Zhu, Linyong^*

来源：Chemical Communications, 2018, 54(10): 1249-1252.

DOI：10.1039/c7cc09200h

• SELECTIVE TRANSMEMBRANE TRANSPORT
• ANION TRANSPORTERS
• ION CHANNELS
• STABILITY
• APOPTOSIS
• MEMBRANE

A unimolecular ion channel was optimized by functionalization with a new type of rigid-rod oligomer. The macrocycle pendant endows chloride selectivity and the fluorescence feature and suitable length of the rod facilitates the visual insertion of channels into the lipid bilayer, resulting in efficient ion transport with an EC50 value of 0.36 mu M.

• 出版日期2018-2-4
• 单位华东理工大学