Multifractal analysis of the UV/VIS spectra of malignant ascites: Confirmation of the diagnostic validity of a clinically evaluated spectral analysis

作者：Reljin Irini S; Reljin Branimir D^*; Avramov Ivic Milka L; Jovanovic Dusan V; Plavec Goran I; Petrovic Slobodan D; Bogdanovic Gordana M

来源：Physica A: Statistical Mechanics and Its Applications , 2008, 387(14): 3563-3573.

DOI：10.1016/j.physa.2008.02.029

• ascites
• neoplasm
• medical diagnosis
• UV/VIS spectroscopy
• Fractals
• multifractal analysis

Multifractal (MF) approach was applied for the analysis of ultraviolet/visible (UV/VIS) spectra as an independent confirmation of the diagnostic efficacy of UV/VIS spectral analysis of intraperitoneal fluids, ascites, taken from patients with a known clinical diagnosis. Recently, it was reported that from UV/VIS spectra differentiation of malignant from benign ascites is possible. Here, it was shown that by using MF analysis of UV/VIS spectra, the objective classification of UV/VIS spectra is possible. The applicability of UV/VIS analysis and MF classification of spectra were evaluated on N = 68 cases, of which M = 64 and B = 4 were clinically confirmed as malignant and benign, respectively. The overall diagnostic efficacy was 89.71% when using on-line analysis of UV/VIS spectra (61 out of 68 samples were positively recognized: 58 malignant and 3 benign), and even 95.59% by using off-line MF classsification (65 out of 68 samples were classified correctly: 63 malignant and 2 benign). It can be inferred that UV/VIS spectral analysis of ascites, combined with MF analysis, could be suggested as a successful and safe screening method in the evaluation of intraperitoneal fluids.

• 出版日期2008-6-1
• 单位中国人民解放军军事医学科学院