Mechanical Stress Acts via Katanin to Amplify Differences in Growth Rate between Adjacent Cells in Arabidopsis

作者：Uyttewaal Magalie; Burian Agata; Alim Karen; Landrein Benoi T; Borowska Wykret Dorota; Dedieu Annick; Peaucelle Alexis; Ludynia Michal; Traas Jan; Boudaoud Arezki^*; Kwiatkowska Dorota; Hamant Olivier

来源：Cell, 2012, 149(2): 439-451.

DOI：10.1016/j.cell.2012.02.048

The presence of diffuse morphogen gradients in tissues supports a view in which growth is locally homogenous. Here we challenge this view: we used a high-resolution quantitative approach to reveal significant growth variability among neighboring cells in the shoot apical meristem, the plant stem cell niche. This variability was strongly decreased in a mutant impaired in the microtubule-severing protein katanin. Major shape defects in the mutant could be related to a local decrease in growth heterogeneity. We show that katanin is required for the cell%26apos;s competence to respond to the mechanical forces generated by growth. This provides the basis for a model in which microtubule dynamics allow the cell to respond efficiently to mechanical forces. This in turn can amplify local growth-rate gradients, yielding more heterogeneous growth and supporting morphogenesis.

• 出版日期2012-4-13