Multifunctional Au@IPN-pNIPAAm nanogels for cancer cell imaging and combined chemo-photothermal treatment

作者：Zhao, Xue-qin; Wang, Tian-xiao; Liu, Wen; Wang, Cai-ding; Wang, Dong; Shang, Ting; Shen, Li-hua; Ren, Lei^*

来源：Journal of Materials Chemistry, 2011, 21(20): 7240-7247.

DOI：10.1039/c1jm10277j

• GOLD NANOPARTICLES
• DRUG-DELIVERY
• SHAPE DEPENDENCE
• THERAPY
• CYTOTOXICITY
• TEMPERATURE
• COPOLYMERS
• HYDROGELS
• POLYMERS
• RELEASE

A facile approach was established for fabricating photothermo-responsive nanogels for simultaneous optical temperature-sensing, cell imaging, and combined chemo-photothermal treatment. The strategy for preparing the hybrid Au@IPN-pNIPAAm nanogels involved two steps, consisting of growing an acrylamide monolayer on a single gold nanoparticle, followed by in situ polymerization and crosslinking of N-isopropylacrylamide and acrylamide. The hybrid Au@IPN-pNIPAAm nanogels exhibited not only biocompatibility at low concentration <200 mu g ml(-1), but also good function on cellular imaging by using dark-field microscopy. Furthermore, the integration of the unique scattering properties of AuNP core and the reversible thermo-responsive volume phase transition of IPN-pNIPAAm shell could offer a thermo-/photo-triggered release of a model anticancer drug 5-fluorouracil from Au@IPN-pNIPAAm nanogels. Hence, the hybrid Au@IPN-pNIPAAm nanogels, may offer broad opportunities for combined diagnosis and therapy.

• 出版日期2011
• 单位厦门大学