Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

作者:Lam Jonathan K; Schmidt Yvonne; Vanderwal Christopher D*
来源:Organic Letters, 2012, 14(21): 5566-5569.
DOI:10.1021/ol302680m

摘要

The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.

  • 出版日期2012-11-2