Assessment of bactericidal effects of quaternary ammonium-based antibacterial monomers in combination with colloidal platinum nanoparticles

作者：Ma, Sai; Izutani, Naomi; Imazato, Satoshi^*; Chen, Ji-hua; Kiba, Wakako; Yoshikawa, Ranna; Takeda, Kahoru; Kitagawa, Haruaki; Ebisu, Shigeyuki

来源：Dental Materials Journal, 2012, 31(1): 150-156.

DOI：10.4012/dmj.2011-180

• Antibacterial monomer
• Quaternary ammonium
• Platinum nanoparticles
• Bactericidal effects

Pretreatment of dentin using colloidal platinum nanoparticles (CPtN) can enhance the bond strength of dentin adhesives. However, the combination of CPtN, which is negatively charged, with cationic monomer-containing adhesive may reduce the antibacterial activity of the original material. Thus, the purpose of this study was to assess the effect of CPtN on the bactericidal activity of two cationic antibacterial monomers, 12-methacryloyloxydodecylpyridinium bromide (MDPB) and methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB). The rapid killing effects of the two monomers against planktonic or attached Streptococcus mutans in the presence or absence of CPtN were examined by viable cell counts. The measurement of minimum inhibitory and bactericidal concentrations demonstrated that CPtN up to 2.5 mM has no antibacterial activity. In the absence of CPtN, rapid killing of both planktonic and attached Streptococcus nuttans were achieved by the two cationic monomers. Combination with 0.1 mM CPtN did not reduce the bactericidal effects of the two monomers, indicating that CPtN may be used as a pretreatment with antibacterial adhesives.

• 出版日期2012-1
• 单位第四军医大学; 中国人民解放军空军军医大学