Decalepis hamiltonii Inhibits Tumor Progression and Metastasis by Regulating the Inflammatory Mediators and Nuclear Factor kappa B Subunits

作者：Shathish Kittappa; Guruvayoorappan Chandrasekharan^*

来源：Integrative Cancer Therapies, 2014, 13(2): 141-151.

DOI：10.1177/1534735413502075

• Decalepis hamiltonii
• metastasis
• proinflammatory cytokines
• nuclear factor kappa B

Metastasis is an extremely complex process that is a major problem in the management of cancer. In the present study, we had evaluated the antimetastatic activity of Decalepis hamiltonii using B16F-10 melanoma-induced experimental lung metastasis in a C57BL/6 mice model. D hamiltonii treatment significantly (P < .01) inhibited lung tumor nodule formation and reduced the lung collagen hydroxyproline, hexosamine, and uronic acid levels. Similarly serum sialic acid and -glutamyl transpeptidase levels were also significantly inhibited after D hamiltonii treatment. The levels of proinflammatory cytokines such as tumor necrosis factor , interleukin (IL)-1, IL-6, granulocyte monocyte colony-stimulating factor, and IL-2 in the serum of these animals were significantly altered after D hamiltonii treatment. The serum NO level was also found to be significantly decreased after D hamiltonii treatment. This decreased NO level after D hamiltonii treatment was also accompanied by decreased inducible NO synthase and cyclooxygenase-2 expression. The study reveals that D hamiltonii treatment could alter proinflammatory cytokine production and could inhibit the activation and nuclear translocation of p65 and p50 subunits of nuclear factor B in B16F-10 cells.

• 出版日期2014-3