A novel and efficient route for the preparation of atorvastatin

作者：Gao, Jian; Guo, Yang Hui; Wang, Ya Ping; Wang, Xiang Jing; Xiang, Wen Sheng^*

来源：Chinese Chemical Letters, 2011, 22(10): 1159-1162.

DOI：10.1016/j.cclet.2011.04.016

• Atorvastatin
• Horner-Wadsworth-Emmons reaction
• Synthesis
• Intermediate

A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.

• 出版日期2011-10
• 单位东北农业大学