Alterations of folliculogenesis in women with polycystic ovary syndrome

作者：Analia Sander Valeria; Belen Hapon Maria; Sicaro Laura; Pedro Lombardi Eduardo; Alma Jahn Graciela; Beatriz Motta Alicia

来源：Journal of Steroid Biochemistry and Molecular Biology, 2011, 124(1-2): 58-64.

DOI：10.1016/j.jsbmb.2011.01.008

• Follicles
• Polycystic ovary syndrome
• Progesterone
• Estradiol
• GATA
• Steroidogenesis

The objective of the present study was to examine some factors involved in follicular development of women with polycystic ovary syndrome (PCOS). Women with PCOS showed increased levels of serum luteinizing hormone (LH) but decreased follicular production of progesterone and estradiol by pre-ovulatory follicles. The mRNA expression corresponding to steroidogenic acute regulatory protein (StAR), and 20alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) was increased, while that corresponding to cytochrome P450 aromatase (P450arom) was decreased in PCOS follicles as compared to controls. No changes in the mRNA expression for 3beta-hydroxysteroid dehydrogenase 2 (3 beta-HSD2), cytochrome P450 side-chain cleavage (P450scc), cytochrome P450 17 alpha hydroxylasegyase (P450c17), cyclooxygenase 2 (COX2), and transcription factors (GATA-4 and GATA-6) were found. We conclude that despite the hyper-luteinized environment of PCOS follicles, these follicles produce lower levels of progesterone and estradiol, and that this is characterized by increased degradation of progesterone and decreased estradiol synthesis. Our data demonstrate that the synthesis of prostaglandin F2 alpha (PGF2 alpha) may be affected in PCOS-follicles and that the transcription factors GATA-4 and GATA-6 are present in PCOS-follicles but they are not involved in the abnormal transcription observed in the steroidogenic enzymes.

• 出版日期2011-3