Fosfomycin Synergy In Vitro with Amoxicillin, Daptomycin, and Linezolid against Vancomycin-Resistant Enterococcus faecium from Renal Transplant Patients with Infected Urinary Stents

作者：Descourouez Jillian L; Jorgenson Margaret R; Wergin Justine E; Rose Warren E^*

来源：Antimicrobial Agents and Chemotherapy, 2013, 57(3): 1518-1520.

DOI：10.1128/AAC.02099-12

Fosfomycin is a potential option for vancomycin-resistant enterococcus (VRE) infections despite limited in vitro and clinical data. In this study, 32 VRE isolates from renal transplant patients with urinary stent infections were susceptible to fosfomycin, daptomycin, and linezolid and resistant to amoxicillin, minocycline, and nitrofurantoin based on their MIC(50)s and MIC(90)s. Fosfomycin was bacteriostatic at 0.5 to 16x the MIC (32 to 2,048 mu g/ml); synergy occurred when fosfomycin was combined with daptomycin (2.8 to 3.9 log(10) CFU/ml kill; P<0.001) or amoxicillin (2.6 to 3.4; P<0.05). These combinations may be potent options to treat VRE urinary infections pending investigation of clinical efficacy.

• 出版日期2013-3