Age-related changes in short-interval intracortical facilitation and dexterity

作者：Clark Jordana; Loftus Andrea; Hammond Geoff^*

来源：NeuroReport, 2011, 22(10): 499-503.

DOI：10.1097/WNR.0b013e3283487480

• aging
• manual dexterity
• motor control
• motor cortex
• short-interval intracortical facilitation
• transcranial magnetic stimulation

Functional changes in the primary motor cortex might contribute to age-related decline in fine motor control. We measured short-interval intracortical facilitation (SICF) in an intrinsic hand muscle with paired-pulse transcranial magnetic stimulation at interstimulus intervals (ISIs) of 1.5, 2.5, and 4.5ms in young and old participants and examined its association with dexterity. We found age-related effects in SICF, with greater facilitation in old than young participants at the 1.5-ms ISI and greater facilitation in young than old participants at the 2.5-ms ISI. SICF at the 2.5-ms ISI was positively correlated with performance on a task that required coordinated and dextrous use of both hands, suggesting that this measure indicates a capacity for executing demanding manual tasks.

• 出版日期2011-7-13