科研之友
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摘要
The Pd-catalyzed cross-coupling ethoxycarbonylation of aryl boronic acids with N-aryl-alpha-iminoesters affords aryl carboxylic esters via carbonyl-imino a bond cleavage. This unprecedented mode of reaction allows regioselective installation of the ethoxycarbonyl group into target molecules. Mechanism studies have revealed that an unusual 1,2-aryl shift process is involved in the transformation.
