A Simple and Efficient Preparation of Pyrazolo[3,4-b]-pyridine Derivatives Through an Unexpected Reaction of Cyanothioacetamide Under Microwave Irradiation

作者：Fan Xuesen^*; Wang Xia; Zhang Xinying; Li Xiaoyan; Qu Guirong

来源：Heteroatom Chemistry, 2008, 19(7): 694-699.

DOI：10.1002/hc.20497

An unexpected multicomponent reaction of cyanothioacetamide with aromatic aldehydes and aminopyrazole under MWI was found and reported. It turned out to be an efficient and simple procedure for the preparation of pyrazolo[3,4-b]pyridine derivatives. The structure of the product was characterized by IR, MS, (1)H and (13)C NMR, COSY and NOESY spectroscopy, X-ray crystallographic analysis, and by comparison with the authentic sample prepared with the known procedure.

• 出版日期2008
• 单位河南师范大学