Mutual sensitization mechanism and self-degradation property of drug delivery system for in vitro photodynamic therapy

作者：Ding, Yi; Zhou, Lin^*; Chen, Xin; Wu, Qi; Song, Ziyi; Wei, Shaohua; Zhou, Jiahong; Shen, Jian

来源：International Journal of Pharmaceutics, 2016, 498(1-2): 335-346.

DOI：10.1016/j.ijpharm.2015.12.044

• Hypocrellin A
• Graphene oxide
• TiO2
• Cancer
• Mutual sensitization
• Self-degradation

In this manuscript, a photosensitive anti-cancer drug, hypocrellin A (HA), and TiO2 nanoparticles were co-loaded on the surface of graphene oxide (GO) as a photosensitive drug delivery system. In vitro studies have demonstrated the active uptake of the system into the mitochondrial of tumor cells. Such system has mutual sensitization mechanism to greatly improve the reactive oxygen species (ROSs) generation ability of the complex by visible light irradiation and, thereby, the strong photodynamic therapy (PDT) efficacy. Furthermore, during such PDT process, GO can be destroyed by the ROSs, which would helpful for the metabolism of this drug delivery system.

• 出版日期2016-2-10
• 单位南京师范大学