Nasal juvenile angiofibroma: Current perspectives with emphasis on management

作者：Lopez Fernando^*; Triantafyllou Asterios; Snyderman Carl H; Hunt Jennifer L; Suarez Carlos; Lund Valerie J; Strojan Primoz; Saba Nabil F; Nixon Iain J; Devaney Kenneth O; Alobid Isam; Bernal Sprekelsen Manuel; Hanna Ehab Y; Rinaldo Alessandra; Ferlito Alfio

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2017, 39(5): 1033-1045.

DOI：10.1002/hed.24696

• embolization
• endoscopy
• juvenile nasopharyngeal angiofibroma
• sinonasal tumors
• surgery

Juvenile angiofibroma is an uncommon, benign, locally aggressive vascular tumor. It is found almost exclusively in young men. Common presenting symptoms include nasal obstruction and epistaxis. More advanced tumors may present with facial swelling and visual or neurological disturbances. The evaluation of patients with juvenile angiofibroma relies on diagnostic imaging. Preoperative biopsy is not recommended. The mainstay of treatment is resection combined with preoperative embolization. Endoscopic surgery is the approach of choice in early stages, whereas, in advanced stages, open or endoscopic approaches are feasible in expert hands. Postoperative radiotherapy (RT) or stereotactic radiosurgery seem valuable in long-term control of juvenile angiofibroma, particularly those that extend to anatomically critical areas unsuitable for complete resection. Chemotherapy and hormone therapy are ineffective. The purpose of the present review was to update current aspects of knowledge related to this rare and challenging disease.

• 出版日期2017-5