Aluminum chloride-mediated yinetic resolution of racemic gamma-substituted-gamma-lactones

作者：Patil ST; Karnik **^*

来源：Chirality, 2004, 16(5): 336-338.

DOI：10.1002/chir.20036

• gamma-substituted-gamma-lactones
• kinetic resolution
• (S)-(-)-1-phenylethylamine
• anhydrous aluminum chloride

Preparation of chiral gamma-substituted-gamma-lactones (1) through kinetic resolution is described. (S)-(-)-1-Phenylethylamine (2) in the presence of anhydrous AICl(3) shows satisfactory levels of enantioselection in reaction with racemic gamma-substituted-gamma-lactones 1, where (R) - 1 remains unreacted, while (S) - 1 is enantioselectively converted to the ring-opened amide (S,S)-4. The enantiopurity of (R)-(+)- gamma-substituted gamma-lactones recovered ranges from 62-98% ee.

• 出版日期2004-5-15