Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

作者：Naidoo Jacinth; Bemben Christopher J; Allwein Shawn R; Liang Jue; Pieper Andrew A; Ready Joseph M^*

来源：Tetrahedron Letters, 2013, 54(33): 4429-4431.

DOI：10.1016/j.tetlet.2013.06.024

• Neuroprotective
• Synthesis
• Carbazole
• Fluorination

A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents and primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.

• 出版日期2013-8-14