A Case of Prolidase Deficiency Accompanying Leg Ulcers

作者：Solak Berna^*; Kara Rabia Oztas; Erdem Teoman; Muftuoglu Tuba

来源：The International Journal of Lower Extremity Wounds, 2015, 14(1): 92-94.

DOI：10.1177/1534734615570360

• prolidase deficiency
• leg ulcer
• hydrocolloid gel

Prolidase deficiency (PD) is a rare autosomal recessive disorder that has symptoms such as skin ulcers, characteristic facies, mental retardation, skeletal deformities, hematological anomalies, splenomegaly, and chronic infections. Deficiency of prolidase leads to the increased excretion of proline in urine, which causes impaired collagen synthesis and delay in wound healing. This case reports a 40-year-old female who has had cutaneous ulcers since the age of 7 years. We also recognized borderline intellectual functioning as well as hematologic abnormalities and splenomegaly. We present this rare case to draw attention to consider prolidase deficiency in the differential diagnosis of leg ulcers.

• 出版日期2015-3
• 单位中国人民解放军军事医学科学院