An outbreak of hepatitis A in recently vaccinated students from ice snacks made from contaminated well water

作者：Zhang L J; Wang X J; Bai J M; Fang G; Liu L G^*; Zhang Y; Fontaine R E

来源：Epidemiology and Infection, 2009, 137(3): 428-433.

DOI：10.1017/S0950268808001337

• Disease outbreaks
• hepatitis A
• hepatitis A vaccines
• water-borne

On 30 May 2006, township S in Sichuan Province, China, reported an outbreak of hepatitis A (HA) in students who had recently received HA vaccine. The concern was raised that the vaccine had caused the outbreak. We attempted to identify the source of infection and mode of transmission. A HA case was defined as onset of jaundice or anorexia since I April 2006 with a twofold elevation of alanine aminotransferase (ALT) and anti-HA virus-IgM in a resident of or visitor to the township. Exposures to vaccine and snacks of 90 case-students to those of 107 control-students were compared. Thirty-four per cent of cases ate ice slush compared to 4.7% of controls (OR 4.1), and 51% of cases ate snow cones compared to 17% of controls (OR 8.3). The ice snacks were made with well water. HA virus RNA was detected by reverse transcription-polymerase chain reaction from patients' blood and well water. Untreated well water poses important dangers to the public in areas where piped, potable water is available.

• 出版日期2009-3
• 单位四川省疾病预防控制中心