A Gelatin-Thrombin Matrix Topical Hemostatic Agent (Floseal) in Combination With Harmonic Scalpel Is Effective in Patients Undergoing Total Thyroidectomy: A Prospective, Multicenter, Single-Blind, Randomized Controlled Trial

作者：Docimo Giovanni^*; Tolone Salvatore; Conzo Giovanni; Limongelli Paolo; Del Genio Gianmattia; Parmeggiani Domenico; De Palma Maurizio; Lupone Gennaro; Avenia Nicola; Lucchini Roberta; Monacelli Massimo; Gulotta Gaspare; Scerrino Gregorio; Pasquali Daniela; Bellastella Giuseppe; Esposito Katherine; De Bellis Annamaria; Pezzolla Angela; Ruggiero Roberto; Docimo Ludovico

来源：Surgical Innovation, 2016, 23(1): 23-29.

DOI：10.1177/1553350615596638

• Floseal
• total thyroidectomy
• gelatin-thrombin matrix
• hemostatic agent
• harmonic scalpel

Background. Hemostasis during thyroidectomy is essential; however, the safest, most efficient, and most cost-effective way to achieve this is unclear. This randomized, multicenter, single-blind, prospective study evaluated the efficacy and safety of using different hemostatic approaches in patients undergoing total thyroidectomy. Methods. Patients aged 18 to 70 years were randomized to Floseal + a harmonic scalpel (HS), Floseal alone, HS alone, or standard total thyroidectomy. Primary endpoint was 24-hour drain output. Secondary endpoints included surgery duration and complications. Results. Two hundred and six patients were randomized to Floseal + HS (n = 52), Floseal alone (n = 54), HS alone (n = 50), and standard total thyroidectomy (n = 50). The 24-hour drain output was lower in the Floseal + HS group compared with standard thyroidectomy. Floseal + HS also had a shorter surgery time (P < .0001) versus the other 3 treatments. Conclusion. Floseal + HS can be effective at reducing postsurgical drain output and provides a complementary hemostatic approach in patients undergoing total thyroidectomy.

• 出版日期2016-2
• 单位Perugia