A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp 1H-GS5

作者：Liu, Chong-Xi; Liu, Shuang-He; Zhao, Jun-Wei; Zhang, Ji; Wang, Xiang-Jing; Li, Jian-Song; Wang, Ji-Dong^*; Xiang, Wen-Sheng^*

来源：Journal of Asian Natural Products Research, 2017, 19(9): 924-929.

DOI：10.1080/10286020.2016.1254200

• Spectinabilin derivative
• ant-derived strain
• Streptomyces sp 1H-GS5
• cytotoxicity

A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC50 values of 9.7, 12.8, and 9.1g/ml, respectively, which was relative higher than that of spectinabilin.
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• 出版日期2017
• 单位东北农业大学