A new ionone derivative from the leaves of Picrasma quassioides

作者:Liu, Chang; Cheng, Rong-Rong; Han, Zhu-zhen; Yang, Ying-bo; Zhou, Yue; Yang, Li; Wang, Zheng-Tao*
来源:Journal of Asian Natural Products Research, 2019, 21(7): 652-658.
DOI:10.1080/10286020.2018.1464561

摘要

Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2-9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 mu M) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents. [GRAPHICS] .