Anti-human-cytomegalovirus immunoglobulin G levels in glioma risk and prognosis

作者：Amirian E Susan; Marquez Do Deborah; Bondy Melissa L; Scheurer Michael E^*

来源：Cancer Medicine, 2013, 2(1): 57-62.

DOI：10.1002/cam4.44

• Brain neoplasms
• glioma
• human cytomegalovirus
• immunoglobulin G
• immunoglobulin M
• risk factors

The role of human cytomegalovirus (HCMV) in glioma development and progression remains controversial. The purpose of our study was to assess the potential associations between anti-HCMV antibodies (immunoglobulin G [IgG] and immunoglobulin M [IgM]) and glioma risk and prognosis using data from the Harris County Case-Control Study. Multivariable logistic regression models were utilized to estimate odds ratios and 95% confidence intervals (CI) for the associations between glioma status and antibody levels among glioma cases (n = 362) and cancer-free controls (n = 462). Hazard ratios and 95% CIs were calculated using Cox proportional hazards regression, adjusting for age, race, and sex, to determine if antibody levels were associated with survival over time among cases. Among IgG-positive participants, increasing anti-HCMV IgG levels were associated with decreasing glioma risk (P for trend = 0.0008), and those with the lowest level of anti-HCMV IgG (%26lt;10 U/mL) had the highest glioma risk, controlling for age, sex, and race/ethnicity (OR: 2.51, 95% CI: 1.424.43). Antibody levels were not associated with survival among glioma cases. Our study contributes new evidence toward the potential importance of the direct and indirect effects of HCMV infection in gliomagenesis.

• 出版日期2013-2