Sparfloxacin-metal complexes as antifungal agents - Their synthesis, characterization and antimicrobial activities

作者：Sultana Najma^*; Arayne M Saeed; Gul Somia; Shamim Sana

来源：Journal of Molecular Structure, 2010, 975(1-3): 285-291.

DOI：10.1016/j.molstruc.2010.04.038

• Sparfloxacin
• Metal complexes
• IR
• NMR
• Elemental analyses
• Antimicrobial activities

Metal complexes with the third-generation quinolone antibacterial agent sparfloxacin (SPFX) or 5-amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8,di-fluoro-1-4-dihydro-4-oxo-3-qunocarboxylic acid have been synthesized and characterized with physicochemical and spectroscopic techniques such as TLC, IR, NMR and elemental analyses. In these complexes, sparfloxacin acts as bidentate deprotonated ligands bound to the metal through the pyridone oxygen and one carboxylate oxygen. The antimicrobial activity of these complexes has been evaluated against four Gram-positive and seven Gram-negative bacteria. Antifungal activity against five different fungi has been evaluated and compared with reference drug sparfloxacin. Fe(2+)-SPFX and Cd(2+)-SPFX complexes showed remarkable potency as compared to the parent drug.

• 出版日期2010-6-30