Ancient, highly conserved proteins from a LUCA with complex cell biology provide evidence in support of the nuclear compartment commonality (NuCom) hypothesis

作者：Staley James T; Fuerst John A

来源：Research in Microbiology, 2017, 168(5): 395-412.

DOI：10.1016/j.resmic.2017.01.001

• LUCA
• PVC superphylum
• Planctomycetes
• Verrucomicrobia
• Origin of eukaryotes
• Ancient cell compartmentalization

The nuclear compartment commonality (NuCom) hypothesis posits a complex last common ancestor (LUCA) with membranous compartments including a nuclear membrane. Such a LUCA then evolved to produce two nucleated lineages of the tree of life: the Planctomycetese-Verrucomicrobiae-Chlamydia superphylum (PVC) within the Bacteria, and the Eukarya. We propose that a group of ancient essential protokaryotic signature proteins (PSPs) originating in LUCAwere incorporated into ancestors of PVC Bacteria and Eukarya. Tubulins, ubiquitin system enzymes and sterol-synthesizing enzymes are consistent with early origins of these features shared between the PVC superphylum and Eukarya.

• 出版日期2017-6