Applications of 4,4 '-(Me3Si)(2)-BINAP in transition-metal-catalyzed asymmetric carbon-carbon bond-forming reactions

作者：Ogasawara M^*; Ngo HL; Sakamoto T; Takahashi T; Lin W

来源：Organic Letters, 2005, 7(14): 2881-2884.

DOI：10.1021/ol050834s

A recently developed BINAP derivative with trimethylsilyl substituents on the 4- and 4 '-positions of the binaphthyl skeleton, 2,2 '-bis-(diphenylphosphino)-4,4 '-bis(trimethylsilyl)-1,1 '-binaphthyl (tms-BINAP), was used in a variety of transition-metal-catalyzed asymmetric carbon-carbon bond-forming reactions. In pi-allylpalladium-mediated reactions, tms-BINAP gave better enantioselectivity than the unsubstituted BINAP, and the origin of the improved enantioselectivity was gained from an X-ray structural study of [Pd(eta(3)-C3H5)((R)-tms-BINAP)]CIO4.

• 出版日期2005-7-7