Atypical, invasive, recurring Crooke cell adenoma of the pituitary

作者：Rotondo Fabio^*; Cusimano Michael; Scheithauer Bernd W; Coire Claire; Horvath Eva; Kovacs Kalman

来源：Hormones-International Journal of Endocrinology and Metabolism, 2012, 11(1): 94-100.

DOI：10.1007/bf03401542

• Crooke cell adenoma
• Histology
• Immunohistochemistry
• Neoplasm
• Ultrastructure

We report the case of a 49-year-old woman presenting with Cushing disease and visual disturbance. An atypical, aggressive, invasive pituitary tumor regrew despite several surgeries. Detailed morphologic investigation by histology, immunohistochemistry and electron microscopy documented a Crooke cell adenoma, a rare form of ACTH-producing pituitary tumor. Recognition of such adenomas is of importance given their aggressive behavior and tendency to recur. More studies are needed to explain the pathobiology of this not invariably functional pituitary adenoma.

• 出版日期2012-3