Annulation of alpha,beta-Unsaturated Imines and Alkynes via Cobalt-Catalyzed Olefinic C-H Activation

作者：Yamakawa Takeshi; Yoshikai Naohiko^*

来源：Organic Letters, 2013, 15(1): 196-199.

DOI：10.1021/ol303259m

A cobalt-triarylphosphine catalyst promotes an annulation reaction of an alpha,beta-unsaturated imine and an internal alkyne to afford a polysubstituted dihydropyridine derivative in good yield under mild conditions. The reaction likely involves alkenylation of the olefinic C-H bond via cobalt-mediated nitrogen-assisted C-H activation followed by facile 6 pi electrocyclization of the resulting azatriene intermediate.

• 出版日期2013-1-4
• 单位南阳理工学院