Application of magnetic resonance spectroscopy in the preoperative grading of gliomas

作者：Shen, Xiao; Wang, Ersong^*; Yao, Chengjun; Tang, Weijun; Guo, Jun

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(2): 2834-2841.

• Proton magnetic resonance spectroscopy
• neuronavigation
• biopsy
• glioma
• brain tumors

This study aims to assess Proton Magnetic Resonance Spectroscopy (1H-MRS) for diagnosis and preoperative grading of cerebral gliomas. A multi point biopsy under 1H-MRS metabolism imaging guidance in 21 cerebral glioma patients was performed preoperatively to obtain the corresponding voxel tissue samples. The gliomas were graded according to MRS and results compared with routine MRI and pathology data, respectively. One hundred and sixteen tissue samples were obtained by biopsy, and the puncture target exactly matched the selected voxel. Choline/N-acetyl aspartate (Cho/NAA) ratios positively correlated with pathological grades (r=0.368, P=0.031). The Cho/NAA ratio was 2.52 with a maximum Youden index of 0.7; based on these results, MRS had 92.9% sensitivity, 71.4% specificity, and 85.7% accuracy, and was more favorable than routine plain and enhanced MRI with 64.3% sensitivity, 85.7% specificity, and 71.4% diagnosis accordance (P=0.040). MRS may contribute to accuracy improvement for grading cerebral gliomas prior to operation.

• 出版日期2017
• 单位复旦大学