A Convenient Method for the Synthesis of Chromeno[4,3-b]pyridines via Three-component Reaction

作者：Nikookar Hamideh; Moghimi Setareh; Sayahi Mohammad Hosein; Mahdavi Mohammad; Ranjbar Parviz Rashidi; Firoozpour Loghman; Foroumadi Alireza^*

来源：Combinatorial Chemistry & High Throughput Screening, 2018, 21(5): 344-348.

DOI：10.2174/1386207321666180524110635

• Pyridocoumarin
• multi-component reaction
• 4-amino coumarin
• one-pot
• 4-hydroxy coumarin
• ammonia

Aim and Objective: The importance of Chromeno[4,3-b]pyridmes in bioactive compounds, highlighted the ongoing research on developing novel methods for the construction of this heterocyclic scaffold. Regarding the advantageous features of multi-component reactions in organic synthesis, we will try to synthesize pyridocoumarms through this method.
Materials and Methods: Chromeno[4,3-b]pyridmes were conveniently prepared from a three-component condensation reaction between 4-hydroxy coumarm, ammonia and ethyl 2,4-dioxo-4-arylbutanoates in refluxmg n-propanol. The synthesized compounds were characterized by NMR, IR and Mass spectroscopy.
Results: The reaction proceeded through an in situ formed 4-ammo coumarm, affording eight new target compounds in good yields.
Conclusion: This method introduce a novel approach to ethyl 4-aryl-5-oxo-5H-chromeno[4,3-b]pyridme-2-carboxylate derivatives and allow organic chemists to prepare 4-ammocoumarm in reaction medium.

• 出版日期2018