Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

作者：Thalluri Kishore; Paul Ashim; Manne Srinivasa Rao; Dev Dharm; Mandal Bhubaneswar^*

来源：RSC Advances, 2014, 4(88): 47841-47847.

DOI：10.1039/c4ra09091h

The synthesis of peptide alcohols from peptides bearing C-terminal amide using beta-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.

• 出版日期2014