Asymmetric Henry reaction catalyzed by Cu(I)-based chiral amino alcohol complex

作者：Shen, Tianhua; Qin, Quan; Ni, Hang; Xia, Ting; Zhou, Xiaocong; Cui, Funa; Li, Junqi; Ran, Deqiang; Song, Qingbao^*

来源：Turkish Journal of Chemistry, 2013, 37(6): 966-977.

DOI：10.3906/kim-1210-62

• Chiral amino alcohol
• copper(I) salt
• asymmetric catalysis
• Henry reaction

The Cu(I)-based complex prepared from (S)-2-(furan-2-yl-methylamino)-2-phenylethanol (5c) and CuCl was used as catalyst in enantioselective Henry reactions of arylaldehydes and nitromethane, which gave 89% ee and 95% yield at ambient temperature. The proposed catalytic cycle of an asymmetric Henry reaction was suggested.

• 出版日期2013
• 单位浙江工业大学