Antimicrobial Susceptibilities of a Worldwide Collection of Stenotrophomonas maltophilia Isolates Tested against Tigecycline and Agents Commonly Used for S. maltophilia Infections

作者：Farrell David J^*; Sader Helio S; Jones Ronald N

来源：Antimicrobial Agents and Chemotherapy, 2010, 54(6): 2735-2737.

DOI：10.1128/AAC.01774-09

Antimicrobial susceptibilities were determined for 1,586 isolates of Stenotrophomonas maltophilia from globally diverse medical centers using the Clinical Laboratory Standards Institute broth microdilution method. The combination trimethoprim-sulfamethoxazole (96.0% of isolates susceptible at <= 2 mu g/ml trimethoprim and 38 mu g/ml sulfamethoxazole) and tigecycline (95.5% of isolates sussceptible at <= 2 mu g/ml) were the only antimicrobials tested with >94% susceptibility in all regions. Susceptibility rates for other commonly used were lower than expected and varied geographically. This in vitro data supports tigecycline as a potential candidate for clinical investigations into S. maltophilia infections.

• 出版日期2010-6