Mechanisms of apoptotic phosphatidylserine exposure

作者:Marino Guillermo; Kroemer Guido*
来源:Cell Research, 2013, 23(11): 1247-1248.
DOI:10.1038/cr.2013.115

摘要

It has been a long-standing enigma which scramblase causes phosphatidylserine residues to be exposed on the surface of apoptotic cells, thereby facilitating the phagocytic recognition, engulfment and destruction of apoptotic corpses. In a recent paper in Science, Nagata and coworkers reveal that the scramblases Xkr8 and its C. elegans ortholog, CED-8, are activated by caspase cleavage in apoptotic cells.

  • 出版日期2013-11