Direct electrochemistry of the Ti(IV)-transferrin complex: Probing into the transport of Ti(IV) by human serum transferrin

作者：Shen, Min; Wang, Jing; Yang, Mei; Li, Genxi^*

来源：Electrochemistry Communications, 2011, 13(2): 114-116.

DOI：10.1016/j.elecom.2010.11.027

• Titanium
• Human serum transferrin
• Titanium transport
• Electrochemistry

Human serum transferrin (hTf) is a principal protein that binds to and transports Ti(IV) in blood, so the Ti (IV)-transferrin complex (Ti-2-hTf) is studied in this work with an electrochemical method. While the direct electrochemistry of the complex is achieved after being embedded in a polyethyleneimine (PEI) film, thus a pair of stable, well-defined and quasi-reversible cyclic volammetric peaks can be observed with the formal potential at -639 mV (vs. SCE), the role of reduction of Ti(IV) in trafficking of Ti(IV) by human serum transferrin is also discussed based on the experimental results that Ti2-hTf undergoes a proton-coupled one electron transfer reaction and Ti(R)-transferrin is reduced to Ti(III)-transferrin under a mildly acidic condition. This work may provide more information about the transport of titanium in vivo.

• 出版日期2011-2
• 单位上海大学; 南京大学